Aqueous extracts of cigarette smoke promote the oxidation of low density lipoprotein by peroxidases

FEBS Letters

Hendler, Sheldon¹  Santanam, Nalini²  Parthasarathy, Sampath²  Sanchez, Robert¹ 

[1]Vyrex Corporation, 2159 Avenida de la Playa, La Jolla, CA 92037, USA

[2]Department of Gynecology and Obstetrics, 1639 Pierce Drive, Emory University School of Medicine, Atlanta, GA 30322, USA

关键词: Smoking;    Atherosclerosis;    Cardiovascular disease;    Oxidized low density lipoprotein;    CSE;    cigarette smoke extract;    LDL;    low density lipoprotein;    Ox-LDL;    oxidized low density lipoprotein;    MPO;    myeloperoxidase;    HRP;    horseradish peroxidase;    H2O2;    hydrogen peroxide;    DPPD;    diphenyl phenylenediamine;   

DOI  :  10.1016/S0014-5793(97)01067-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oxidation of low density lipoprotein (LDL) by cigarette smoke has been considered a potential mechanism by which smoking may promote atherosclerosis. We report in this study that cigarette smoke extract (CSE) inhibited copper-induced oxidation of LDL suggesting the presence of antioxidants in CSE. It is currently believed that peroxidases may oxidize LDL in vivo and during such oxidations antioxidants become pro-oxidants. Accordingly, when LDL was oxidized by peroxidase in the presence of CSE there was an increase in the oxidation of LDL. This is the first study suggesting that smoking may promote atherosclerosis by enhancing peroxidase-catalyzed lipid peroxidation.

【 授权许可】

Unknown