Secondhand Smoke Exposure and Subclinical Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis

Secondhand Smoke;Smoking;Atherosclerosis;Inflammation;Subclinical Cardiovascular Disease;Epidemiology

Magid, Hoda SamirNavas-Acien, Ana ;

Johns Hopkins University

关键词: Secondhand Smoke;    Smoking;    Atherosclerosis;    Inflammation;    Subclinical Cardiovascular Disease;    Epidemiology;   

Others  :  https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/40658/MAGID-THESIS-2015.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: JOHNS HOPKINS DSpace Repository

【 摘 要 】

Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease (CVD) among ethnically diverse populations. This study assessed the impact of SHS on three domains of subclinical CVD (inflammation, atherosclerosis, and peripheral arterial disease) among 5,032 non-smoking adults 45-84 years without prior CVD participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002. SHS exposure was determined by self-report, and urinary cotinine in a subset. The multi-adjusted geometric mean ratios (95% confidence interval) of high sensitivity C-reactive protein comparing 407 participants with SHS ≥12 hours/week vs 3,035 unexposed were 1.26 (1.12, 1.41) and 1.14 (1.02, 1.26) before and after adjustment for body mass index, respectively. The corresponding ratios for interleukin 6 were 1.11 (1.04, 1.18) and 1.05 (0.98, 1.11), and for internal carotid intima media thickness they were 1.04 (1.00, 1.09) and 1.04 (0.99, 1.08). Fibrinogen and coronary artery calcification were not associated with SHS. The prevalence of peripheral arterial disease (ABI≤0.9 or ABI≥1.4) was associated with detectable urinary cotinine (Odds ratio: 2.0l; 95% confidence interval: 1.13, 3.90) but not with self-reported SHS. Despite limited exposure assessment, this study supports the association of SHS exposure with hsCRP, and maybe with IL-6, internal cIMT, and peripheral arterial disease.