Examining Smoking-Induced Differential Gene Expression Changes in Buccal Mucosa

Kupfer DM, White VL, Jenkins MC, Burian D

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Buccal Cells;    Smoking;    Differential Gene Expression;    qPCR;    Microarray;   

RP-ID  :  DOT/FAA/AM-10/2

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

Gene expression changes resulting from conditions such as disease, environmental stimuli, and drug use can be monitored in the blood. However, a less invasive method of sample collection is of interest because of the discomfort and specialized personnel necessary for blood sampling, especially if multiple samples are being collected. Buccal mucosa (cheek swabs) are easily collected and may be an alternative sample material for biomarker testing.