Association of Hyperhomocysteinemia with Acute Myocardial Infarction in Kurdish Patients

1st International Conference on Mechanical Electronic and Biosystem Engineering

Othman Amen, Shwan^1 ; Tharwat Baban, Soza^2

Consultant Interventional Cardiologist, Surgical Specialty Hospital, Cardiac Center Erbil, German Board (Facharzt), Interventional Cardiology, German Board (Facharzt) in Internal Medicine, Iraq^1

Biomedical Scientist, Medical Laboratory, Surgical Specialty Hospital- Cardiac Center, Erbil, Iraq^2

关键词: Acute myocardial infarction;    Cardio-vascular risk factors;    Cardiovascular disease;    Case-control study;    Diabetes mellitus;    Endothelial dysfunction;    Hyperhomocysteinemia;    Myocardial Infarction;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/557/1/012083/pdf
DOI  :  10.1088/1757-899X/557/1/012083

来源: IOP

【 摘 要 】

Cardiovascular disease (CVD) is the main cause of death worldwide. Among multiple cardiovascular risk factors, such as age, blood pressure, diabetes, smoking and hyperlipidemia, hyperhomocysteinemia has recently emerged to have an important role in increasing risk of CVD by impairing oxidative stress-induced endothelial dysfunction and inducing atherothrombosis. However, the association between high circulating level of homocysteine and increasing the risk of CVD in human remains controversial and has not been consistently observed. OBJECTIVES: The aim of this study is to evaluate the association between serum total homocysteine (tHcy) concentrations with increased risk of CAD in patients with acute myocardial infarction (MI) in Kurdish population. In addition, correlations of classical risk factors including hypertension, smoking, diabetes and hyperlipidemia with hyperhomocysteinemia in MI patients were studied. Its role in in development of CVD could be pivotal. METHODS: In a case-control study, a total of 74 patients (51 male; 23 female; aged 22-80 years) who had diagnosed with acute CAD on angiography were enrolled in this study and 74 gender and age matched non-CAD individuals were included as the control group. The serum tHcy level was measured by enzymatic immunoassay. Hyperhomocysteinemia (HHcy) was defined as Hcy>15 mol/l. RESULTS: the mean ± standard deviation (SD) of serum total homocysteine (tHcy) level in acute myocardial infarction patients was 22.8 ± 1.30 mol/l, which was significantly higher compared to that of control group being 15.1 ± 1.33 mol/l (P