Expression of lectin‐like oxidized low density lipoprotein receptor‐1 in human and murine macrophages: upregulated expression by TNF‐α

FEBS Letters

Moriwaki, Hideaki²  Sawamura, Tatsuya¹  Kita, Toru²  Murase, Takatoshi²  Masaki, Tomoh¹  Kataoka, Hiroharu²  Kume, Noriaki²  Nishi, Eiichiro² 

[1] Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan

关键词: LOX-1;    Oxidized low density lipoprotein;    Macrophage;    Tumor necrosis factor α;    Atherosclerosis;   

DOI  :  10.1016/S0014-5793(98)01414-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Uptake of oxidized low density lipoprotein (Ox-LDL) and subsequent foam cell transformation have been implicated in early atherogenesis. Although multiple molecules, including class A and B scavenger receptors, have been identified as Ox-LDL receptors, additional receptors may also be involved in this process. Here, we provide evidence that lectin-like Ox-LDL receptor-1 (LOX-1), a novel Ox-LDL receptor initially identified in vascular endothelial cells, is also expressed in macrophages in humans and mice. Expression of LOX-1 can be induced after macrophage-like differentiation in vitro in human peripheral blood monocytes and the related cell line THP-1 cells. Furthermore, LOX-1 expression can also be detected in resident peritoneal macrophages, and can be upregulated by an inflammatory cytokine TNF-α. These results suggest that LOX-1 in macrophages may play an important role in Ox-LDL uptake and subsequent foam cell formation in this cell type.

【 授权许可】

Unknown