Non‐oxidative modification of low density lipoprotein by ruptured myocytes

FEBS Letters

Rice-Evans, Catherine¹  Bourne, Louise C¹  Lamb, David J²  Collis, Cliff S¹  Leake, David S²  O'Brien, Michael¹ 

[1] International Antioxidant Research Centre, UMDS-Guy's Hospital, St Thomas Street, London SE1 9RT, UK;School of Animal and Microbial Sciences, The University of Reading, Reading RG6 6AJ, UK

关键词: Oxidized low density lipoprotein;    Myocyte;    Myoglobin;    Macrophage;    Chymostatin;    [125I]LDL degradation;   

DOI  :  10.1016/S0014-5793(97)01075-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In this study, the interaction of ruptured cardiac myocytes with low density lipoprotein (LDL) has been investigated and the consequent extent of uptake by macrophages. The results show that lysate released from ruptured myocytes is capable of inducing LDL oxidation and that the resulting modified form is recognised and degraded by macrophages. Peroxyl radical scavengers inhibit the LDL oxidation but not the macrophage uptake suggesting that LDL can be modified by mechanisms that are independent of oxidative processes by intracellular constituents of cardiac myocytes.

【 授权许可】

Unknown