A central role for the endothelial NADPH oxidase in atherosclerosis

FEBS Letters

Meyer, Jamie W.¹  Schmitt, Mark E.² 

[1] Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 231 Bethesda Avenue, P.O. Box 670524, Cincinnati, OH 45267-0524, USA;Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA

关键词: Atherosclerosis;    Low density lipoprotein;    Endothelial cell;    NADPH oxidase;    Oxidized low density lipoprotein;   

DOI  :  10.1016/S0014-5793(00)01397-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis. These effects appear to be carried out by both the ability of O₂ ⁻ to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O₂ ⁻. We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease.

【 授权许可】

Unknown