NADPH oxidase activity is required for endothelial cell proliferation and migration

FEBS Letters

Aird, William C.¹  Spokes, Katherine C.¹  Kachra, Zarin¹  Abid, Md.Ruhul¹ 

[1] Departments of Medicine and Molecular Medicine, Beth Israel Deaconess Medical Center, RW-663, 330 Brookline Ave., Boston, MA 02215, USA

关键词: NADPH oxidase;    Reactive oxygen species;    Endothelial cell;    Proliferation;    Migration;   

DOI  :  10.1016/S0014-5793(00)02305-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

NADPH oxidase has been shown to play an important role in cardiovascular biology. The goal of the present study was to determine whether NADPH oxidase activity is important for endothelial cell growth and migration. In proliferation assays, growth factor- or serum-induced DNA synthesis in three different types of human endothelial cells was abrogated by inhibitors of NADPH oxidase, but not by inhibitors of xanthine oxidase or nitric oxide synthase. Moreover, vascular endothelial growth factor-induced migration of human endothelial cells was suppressed in the presence of NADPH oxidase inhibitors. These results support a potential role for NADPH oxidase in mediating angiogenesis.

【 授权许可】

Unknown