COVID-19 and chronic diabetes: the perfect storm for reactivation tuberculosis?: a case series

Journal of Medical Case Reports

John M. Thomas¹  Juan García¹  Eder Ledezma-Campos¹  Brandon Michael Henry²  Juan Ignacio García²  Jordi B. Torrelles²  Joanne Turner²  Doris Ayala³  Genesis P. Aguillón-Durán³  Blanca I. Restrepo⁴  Ericka Prieto-Martínez⁵ 

[1] Department of Human Genetics, South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, 1214 W Schunior, UTRGV-Edinburg Campus, 78541, Edinburg, TX, USA;Population Health Program and Host Pathogens Interactions Program, Texas Biomedical Research Institute, 78229, San Antonio, TX, USA;School of Public Health, University of Texas Health Science Center at Houston, Brownsville Campus, 78520, Brownsville, TX, USA;School of Public Health, University of Texas Health Science Center at Houston, Brownsville Campus, 78520, Brownsville, TX, USA;Department of Human Genetics, South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, 1214 W Schunior, UTRGV-Edinburg Campus, 78541, Edinburg, TX, USA;Secretaria de Salud de Tamaulipas, 88630, Reynosa, Tamaulipas, Mexico;Secretaria de Salud de Tamaulipas, 87000, Ciudad Victoria, Tamaulipas, Mexico;

关键词: Tuberculosis;    COVID-19;    SARS-CoV-2;    Diabetes mellitus;    Type 2 diabetes;    Diagnostic delays;   

DOI  :  10.1186/s13256-021-03193-7

来源: Springer

【 摘 要 】

BackgroundThe coronavirus disease 2019 pandemic is predicted to have a net negative effect on tuberculosis control, with an estimated excess of 6.3 million tuberculosis cases and 1.4 million deaths by 2025. Programmatic issues such as the lockdown of tuberculosis services affect all patients, while biosocial factors have a differential impact on an individual’s risk for tuberculosis or adverse tuberculosis outcomes.Case presentationWe report three Hispanic cases of incident tuberculosis (two males, 43 and 44 years old; one female, 49 years old) after resolution of coronavirus disease episodes. Coincidentally, all cases shared a common risk factor: a chronic history poorly controlled diabetes.ConclusionsOur findings alert to the threat posed by the synergy between coronavirus disease and diabetes, on tuberculosis reactivation. In medium- to high-risk settings for tuberculosis, we recommend implementation of routine screening for latent tuberculosis infection in these cases, and preventive tuberculosis treatment in those who are positive.

【 授权许可】

CC BY