The epidemiology of intransient TB-induced hyperglycaemia in previously undiagnosed diabetes mellitus 2 individuals: a protocol for a systematic review and meta-analysis

Systematic Reviews

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[1] 0000 0001 0604 5662, grid.12155.32, Epidemiology and Social Medicine, University of Hasselt, Hasselt, Belgium;0000 0001 2069 7798, grid.5342.0, Faculty of Medical and Health Sciences, Ghent University, De Pintelaan 185 P3, 9000, Ghent, Belgium;0000 0001 2153 5088, grid.11505.30, Noncommunicable Diseases Unit, Department of Public Health, Institute of Tropical Medicine Antwerp, Antwerp, Belgium;0000 0004 1937 1135, grid.11951.3d, Department of Family Medicine and Primary Care, University of the Witwatersrand, Johannesburg, South Africa;0000 0001 1481 7466, grid.25867.3e, Department of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania;Faculty of Pharmacy, Department of Clinical Pharmacy, Saints Cyril and Methodius University, Skopje, Republic of Macedonia;grid.410868.3, Department of Mathematics, School of Natural Sciences, Shiv Nadar University, Greater Noida, India;

关键词: Tuberculosis;    Diabetes mellitus;    Intransient hyperglycaemia;    Protocol;   

DOI  :  10.1186/s13643-019-1143-0

来源: publisher

【 摘 要 】

BackgroundDiabetes mellitus (DM) is burgeoning as a global chronic health condition. Some studies suggest that tuberculosis (TB) can even cause diabetes in those not previously known to be diabetic, which as a corollary can add to the already heavy global DM burden. The World Health Organization (WHO) recommends screening for DM at the start of TB treatment; however, it remains to be elucidated which patients with TB-induced hyperglycaemia are at risk for developing DM and who would benefit from a more regular follow-up. This systematic review will aim to firstly synthesise literature on the irreversibility of TB-induced hyperglycaemia in individuals with previously undiagnosed type 2 diabetes mellitus and secondly to synthesise literature on risk factors for progression from TB-induced hyperglycaemia to overt DM in previously undiagnosed.MethodsWe will search for relevant studies in electronic databases such as PubMed, EMBASE, PROQUEST, and SCOPUS. Furthermore, references will be hand searched to identify other studies. A flow diagram will be drawn to identify the studies retrieved from each database. We will review all publications that include studies containing data on impaired glucose metabolism upon TB diagnosis, and the quality of all eligible studies will be assessed using the Newcastle-Ottawa Scale. We will further conduct a meta-analysis to pool estimates on the risk of progression of persistent hyperglycaemia to overt DM within this population group, as well as the risk factors for this progression. We will use a random effect model to assess heterogeneity, will carry out sensitivity analysis to explore the influence of a single study on the overall estimate, and will report our findings from our systematic review and meta-analysis according to PRISMA guidelines. Egger’s test will be performed to explore the presence of selective reporting bias. If data allow, we will perform a subgroup/meta-regression analysis. Summary effects will be reported using odds ratio, hazard ratio, and relative risk ratios. Furthermore, any clinical, epidemiological, and public health research gaps we identify will be described in a research proposal.

【 授权许可】

CC BY