Nano-immunoshielding ising multi-layered hyperbranched polyethylene glycol for the nonhuman primates pancreatic islets xenotransplantation

Diabetes mellitus;Surface modification;Pancreatic islet transplantation;Poly ethylene glycol;Monkey islet;Nano-immuno shielding;615

약학대학 약학과 ;

University:서울대학교 대학원

关键词: Diabetes mellitus;    Surface modification;    Pancreatic islet transplantation;    Poly ethylene glycol;    Monkey islet;    Nano-immuno shielding;    615;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133560/1/000000025075.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

0.5% 6-arm PEG NHS, 1% 6-arm PEG DOPA and 0.5% linear PEG SH. Additionally, we made a new immunosuppressive drug protocol. Finally, we treated both immuno shielding and drug protocol and evaluated the islet survival rate and blood glucose.In this research shows that immuno shielded islet can survive more than 3 times longer compare with intact islet with maintaining the normal blood glucose level. So, using this results, we can make the basic allotransplantation protocols in primates. Also human’s islet is similar to the monkey islet, therefore we can predict the result of human allotransplantation.