SARS-CoV-2 pathophysiology and assessment of coronaviruses in CNS diseases with a focus on therapeutic targets

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1866

Review

Vallamkondu, Jayalakshmi¹  John, Albin²  Wani, Willayat Yousuf³  Ramadevi, Suguru Pathinti¹  Jella, Kishore Kumar⁴  Reddy, P. Hemachandra^2,5,6,7,8  Kandimalla, Ramesh^9,10 

[1] Natl Inst Technol, Warangal 506004, Telangana, India

[2] Texas Tech Univ, Hlth Sci Ctr, Internal Med, Lubbock, TX 79430 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA

[4] Emory Univ, Neurooncol, Atlanta, GA 30322 USA

[5] Texas Tech Univ, Hlth Sci Ctr, Internal Med Neurosci & Pharmacol, Lubbock, TX 79430 USA

[6] Texas Tech Univ, Hlth Sci Ctr, Dept Sch Med, Neurol, Lubbock, TX 79430 USA

[7] Texas Tech Univ, Hlth Sci Ctr, Publ Hlth Dept, Grad Sch Biomed Sci, Lubbock, TX 79430 USA

[8] Texas Tech Univ, Hlth Sci Ctr, Dept Speech Language & Hearing Sci, Sch Hlth Profess, Lubbock, TX 79430 USA

[9] Kakatiya Med Coll, Dept Biochem, Warangal 506007, Telangana, India

[10] CSIR, Appl Biol, Indian Inst Technol, Uppal Rd, Hyderabad 500007, Telangana, India

关键词: COVID-19;    Brain;    Neutralizing antibodies;    Diabetes mellitus;    SARS-CoV-2;    Therapeutics;    Multiple sclerosis;   

DOI  :  10.1016/j.bbadis.2020.165889

来源: Elsevier

【 摘 要 】

The novel Coronavirus disease of 2019 (nCOV-19) is a viral outbreak noted first in Wuhan, China. This disease is caused by Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV)-2. In the past, other members of the coronavirus family, such as SARS and Middle East Respiratory Syndrome (MERS), have made an impact in China and the Arabian peninsula respectively. Both SARS and COVID-19 share similar symptoms such as fever, cough, and difficulty in breathing that can become fatal in later stages. However, SARS and MERS infections were epidemic diseases constrained to limited regions. By March 2020 the SARS-CoV-2 had spread across the globe and on March 11th, 2020 the World Health Organization (WHO) declared COVID-19 as pandemic disease. In severe SARS-CoV-2 infection, many patients succumbed to pneumonia. Higher rates of deaths were seen in older patients who had co-morbidities such as diabetes mellitus, hypertension, cardiovascular disease (CVD), and dementia. In this review paper, we discuss the effect of SARS-CoV-2 on CNS diseases, such as Alzheimer's-like dementia, and diabetes mellitus. We also focus on the virus genome, pathophysiology, theranostics, and autophagy mechanisms. We will assess the multiorgan failure reported in advanced stages of SARS-CoV-2 infection. Our paper will provide mechanistic clues and therapeutic targets for physicians and investigators to combat COVID-19.

【 授权许可】

Free