Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity

FEBS Letters

Fiers, Walter¹  Beyaert, Rudi¹ 

[1] Laboratory of Molecular Biology, Gent University, K.L. Ledeganckstraat 35, B-9000 Gent, Belgium

关键词: TNF;    Cytotoxicity;    Phospholipases;    Mitochondria;    Phosphorylation;    Signal transduction;   

DOI  :  10.1016/0014-5793(94)80163-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Although TNF plays an important role in several physiological and pathological conditions, the hallmark of this important cytokine has been its selective cytotoxic activity on tumor cells. Since its cloning in 1984, understanding of how TNF selectively kills tumor cells has been the subject of research in many laboratories. Here we review TNF-induced post-receptor signaling mechanisms which seem to be involved in the pathway to cytotoxicity.

【 授权许可】

Unknown