Search of a solution correction of a lipidic metabolism at acute pancreatitis

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Anaskin, S.G.^1 ; Vlasov, A.P.^2 ; Korniletsky, I.D.^1

National Research Nuclear University, MEPhI, Moscow, Russia^1

N.P. Ogarev Mordovia State University, Saransk, Russia^2

关键词: Acute pancreatitis;    Antioxidant protection;    Calcium channels;    Fabric structures;    Inflammatory process;    Phospholipases;    Pilot studies;    Radical process;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012055/pdf
DOI  :  10.1088/1742-6596/784/1/012055

来源: IOP

【 摘 要 】

Following the results of a pilot study on studying of influence of an emoksipin, verapamil and a reamberin at acute pancreatitis it is possible to say that under the influence of these drugs in fabric structures of the inflamed pancreas there is a decrease in intensity of free radical processes of a lipopereokisleniye, activity of phospholipases, hypoxia phenomena. Level of antioxidant protection of fabric of body increases. In the first three days of supervision the accurate tendency to normalization of the transformed lipidic structure of fabric structures of a pancreas is revealed. At the same time these positive effects are noted in all experienced groups. It demonstrates that though pharmacological drugs are used multidirectional action (antioxidant emoksipin, an antigipoksant reamberin, inhibitor of calcium channels verapamil), they in a varying degree influence on studied pathological (membranodestruktivny, hypoxemic) processes, leading finally to reduction of their expressiveness. So, emoksipin found big ability to increase stability of membranes of pankreatotsit to pathological influence of molecular products the FLOOR, verapamil - to stopping of the activated phospholipases, reamberin - to a hypoxia. The question solution on the key (prevailing) mechanism in trigger processes of sharp pancreatitis of a definite answer has no. Undoubtedly only the fact that efficiency of antioxidant and inhibitor of calcic channels was rather higher. It suggests that free radical processes of a lipopereokisleniye and activity of fosfolipazny systems predetermine the level and nature of defeat of a cellular biomembrane of pankreatotsit already on the earliest terms of inflammatory process.