Both neurotoxin II from venom of Naja naja oxiana and its endogeneous analogue induce apoptosis in tumor cells

FEBS Letters

Satpaev, D.K.¹  Strizhkov, B.N.¹  Karelin, A.A.¹  Blishchenko, E.Yu.¹ 

[1] Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16110, Moscow, GSP-7, 117871, Russian Federation

关键词: Cytotoxicity;    Neurotoxin II;    Apoptosis;    NT II;    neurotoxin II;    NTlm;    Neurotoxin-like material;    TNF;    tumor necrosis factor;    CNS;    central nervous system;    SIRS;    soluble immune response supressor;    IL-1;    interleukin 1;    LT;    lymphotoxin;    TGF;    transforming growth factor;   

DOI  :  10.1016/0014-5793(94)80165-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20–30 kDa proteins partially purified from pig brain (NTlm) cross-reacting with antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10⁻⁶–10⁻⁸ M. Modification of Cys residues significantly reduced cytotoxicity of NT II. Both NT2 and NTlm induced apoptosis in L929 and K562 cells.

【 授权许可】

Unknown