Synthesis, Antioxidant Activity, Acetylcholinesterase Inhibition and Quantum Studies of Thiosemicarbazones

Journal of the Brazilian Chemical Society

Oliveira, Aldo S. de¹  Sens, Larissa² 

[1] Universidade Federal de Santa Catarina, Brazil;Universidade Federal de Santa Catarina, Florianópolis, Brazil

关键词: antioxidants;    acetylcholinesterase;    Alzheimer's disease;    thiosemicarbazone.;   

DOI  :  10.21577/0103-5053.20170146

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Thiosemicarbazones are a class of compounds of interest for Medicinal Chemistry, as they are structurally diverse and have numerous biological activities reported in the literature. This study describes the synthesis of seventeen thiosemicarbazones, which were investigated as potential therapeutic agents for the treatment of Alzheimer's disease through antioxidant tests and an inhibitory assay of the acetylcholinesterase enzyme. All compounds showed excellent inhibition of acetylcholinesterase and exhibited excellent antioxidant action when compared to the standards. In addition, a quantum study was carried out, in which the HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) energy values of each compound were obtained. From these theoretical data, chemical properties were calculated and correlated with the experimental data.

【 授权许可】

CC BY