Development of Tc-99m Imaging Agents for Abeta Plaques

Zhi-Ping, Zhuang ; Mei-Ping Kung ; Catherihne Hou ; Hank F. Kung

关键词: BRAIN;    DIAGNOSIS;    DISEASES;    HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;    IN VITRO;    PATIENTS;    SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;    STILBENE;    TRANSGENIC MICE SPECT imaging;    Alzheimer's disease;    Tc99m;    braib section labeling;   

DOI  :  10.2172/938779
RP-ID  :  ER63589 0009488
PID  :  OSTI ID: 938779
Others  :  TRN: US1001785

学科分类：化学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

Development of SPECT imaging agents based on Tc-99m targeting Aβ plaques is useful for diagnosis of Alzheimer’s disease (AD). A stilbene derivative, [11C]SB-13, showing promise in detecting senile plaques present in AD patients has been reported previously1,2. Based on the 4’-amino-stilbene core structure we have added substituted groups through which a chelating group, N2S2, was conjugated. We report herein a series of Tc-99m labeled stilbene derivative conjugated with a TcO[N2S2] core. The syntheses of stilbenes containing a N2S2 chelating ligand are achieved by a scheme shown. Lipophilic 99mTc stilbene complexes were successfully prepared and purified through HPLC. Preliminary results of in vitro labeling of brain sections from transgenic mice showed very promising plaque labeling. These 99mTc stilbene derivatives are warranted for further evaluations as potential imaging agents targeting amyloid plaques.