Química Nova | |
Natural products as candidates for useful drugs in the treatment of Alzheimer's disease | |
Bolzani, Vanderlan da Silva1  Furlan, Maysa1  Viegas Junior, Cláudio1  Universidade Federal do Rio de Janeiro, Rio de Janeiro1  Barreiro, Eliezer J.1  Fraga, Carlos Alberto Manssour1  Universidade Estadual Paulista 'Júlio de Mesquita Filho', Araraquara1  | |
关键词: Alzheimer's disease; acetylcholinesterase; natural products.; | |
DOI : 10.1590/S0100-40422004000400021 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050593160ZK.pdf | 775KB | download |