Natural products as candidates for useful drugs in the treatment of Alzheimer's disease

Química Nova

Bolzani, Vanderlan da Silva¹  Furlan, Maysa¹  Viegas Junior, Cláudio¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro¹  Barreiro, Eliezer J.¹  Fraga, Carlos Alberto Manssour¹  Universidade Estadual Paulista 'Júlio de Mesquita Filho', Araraquara¹ 

关键词: Alzheimer's disease;    acetylcholinesterase;    natural products.;   

DOI  :  10.1590/S0100-40422004000400021

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors.

【 授权许可】

Unknown