Preliminary study of Alzheimer's Disease diagnosis based on brain electrical signals using wireless EEG

13th South-East Asian Congress of Medical Physics 2015

物理学;医药卫生

Handayani, N.^1,2 ; Akbar, Y.^1 ; Khotimah, S.N.^1 ; Haryanto, F.^1 ; Arif, I.^1 ; Taruno, W.P.^3

Department of Physics, Faculty of Mathematics and Natural Science, Institut Teknologi Bandung, Jl. Ganesa No. 10, Bandung

40132, Indonesia^1

Department of Physics, Faculty of Sciences and Technology, UIN Sunan Kalijaga, Jl. Marsda Adisucipto No. 1, Yogyakarta

55281, Indonesia^2

Neuroscience Laboratory, CTech Labs PT Edwar Technology, Jl. Jalur Sutera Kavling Spektra, No. 10-12 Alam Sutera, Banten, Tangerang, Indonesia^3

关键词: Alpha activities;    Alzheimer's disease;    Electrical signal;    Low frequency band;    Neural complexity;    Neuronal damage;    Power spectral analysis;    Relaxed conditions;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/694/1/012068/pdf
DOI  :  10.1088/1742-6596/694/1/012068

学科分类：卫生学

来源: IOP

【 摘 要 】

This research aims to study brain's electrical signals recorded using EEG as a basis for the diagnosis of patients with Alzheimer's Disease (AD). The subjects consisted of patients with AD, and normal subjects are used as the control. Brain signals are recorded for 3 minutes in a relaxed condition and with eyes closed. The data is processed using power spectral analysis, brain mapping and chaos test to observe the level of complexity of EEG's data. The results show a shift in the power spectral in the low frequency band (delta and theta) in AD patients. The increase of delta and theta occurs in lobus frontal area and lobus parietal respectively. However, there is a decrease of alpha activity in AD patients where in the case of normal subjects with relaxed condition, brain alpha wave dominates the posterior area. This is confirmed by the results of brain mapping. While the results of chaos analysis show that the average value of MMLE is lower in AD patients than in normal subjects. The level of chaos associated with neural complexity in AD patients with lower neural complexity is due to neuronal damage caused by the beta amyloid plaques and tau protein in neurons.