Effects of ethanol on the pathogenesis of Alzheimer's disease

2018 5th International Conference on Advanced Composite Materials and Manufacturing Engineering

Yi, Kaixuan^1 ; Shi, Yue^1 ; Zhao, Yan^1

Department of Bioengineering, Harbin Institute of Technology, Weihai, Shandong

264209, China^1

关键词: Alcohol drinking;    Alzheimer's disease;    Beta amyloids;    Cognitive decline;    Major factors;    Memory loss;    Microtubule associated protein;    Neurodegeneration;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/394/2/022024/pdf
DOI  :  10.1088/1757-899X/394/2/022024

来源: IOP

【 摘 要 】

Alzheimer's disease (AD) is an age-related neurodegenerative disease associated with cognitive decline and memory loss. It has been shown that alcohol drinking affects the mechanisms of neurodegeneration in patients with AD. This paper reviews the effects of alcohol on major factors involved in AD pathogenesis, including the formation and aggregation of beta-amyloid, posttranslational modulation of microtubule-associated proteins, induction of oxidative stress and degeneration of acetylcholine system.