Association of genetic risk factors with cognitive decline: the PATH through life project

NEUROBIOLOGY OF AGING

卷:41

Article

Andrews, Shea J.¹  Das, Debjani¹  Cherbuin, Nicolas²  Anstey, Kaarin J.²  Easteal, Simon¹ 

[1] Australian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, Canberra, ACT 2601, Australia

[2] Australian Natl Univ, Res Sch Populat Hlth, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia

关键词: Alzheimer's disease;    Cognitive decline;    SNPs;    Genetic risk scores;    Population-based study;   

DOI  :  10.1016/j.neurobiolaging.2016.02.016

来源: Elsevier

【 摘 要 】

We examined the association of 28 single nucleotide polymorphisms (SNPs), previously associated with dementia or cognitive performance, with tests assessing episodic memory, working memory, vocabulary, and perceptual speed in 1689 nondemented older Australians of European ancestry. In addition to testing each variant individually, we assessed the collective association of the 12-risk SNPs for late-onset Alzheimer's disease using weighted and unweighted genetic risk scores. Significant associations with cognitive performance were observed for APOE epsilon 4 allele, ABCA7-rs3764650, CR1-rs3818361, MS4A4E-rs6109332, BDNF-rs6265, COMT-rs4680, CTNNBL-rs6125962, FRMD4A-rs17314229, FRMD4A-rs17314229, intergenic SNP chrX-rs12007229, PDE7A-rs10808746, SORL1-rs668387, and ZNF224-rs3746319. In addition, the weighted genetic risk score was associated with worse performance on episodic memory. The identification of genetic risk factors, that act individually or collectively, may help in screening for people with elevated risk of cognitive decline and for understanding the biological pathways that underlie cognitive decline. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

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