Study on Anticancer Activity of Extracts of Sponges Collected from Biak Water, Indonesia

2nd International Conference on Tropical and Coastal Region Eco Development 2016

地球科学;生态环境科学

Trianto, A.^1,2 ; Ridhlo, A.^2 ; Triningsih, D.W.^2 ; Tanaka, J.^3

Natural Product Laboratory, Centre of Research and Services (Laboratorium Terpadu), Diponegoro University, Indonesia^1

Department Marine Science, Faculty of Fisheries and Marine Science, Diponegoro University, Semarang, Indonesia^2

Department Chemistry, Biology and Marine Science, University of Ryukyus, 1-Senbaru, Nishihara, Okinwa, Japan^3

关键词: anti-cancer;    Anticancer activities;    Bioactive compounds;    Biologically active molecules;    extract;    Methanolic extracts;    NBT-T2;    sponge;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/55/1/012069/pdf
DOI  :  10.1088/1755-1315/55/1/012069

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Indonesia is center of biodiversity where marine sponges are abundant. a source of bioactive compounds with various pharmaceutical properties such as anticancer, antifungal, antibacterial, antioxidants, anti-inflammatory, and anti-malarial. In a continuation of a search for biologically active molecules from marine organisms we investigated the potency of marine sponges as anticancer. A total of 106 sponge specimens were collected between 3-40 m depths by SCUBA diving in Biak waters during August 2005. The specimens were extracted with methanol to provided crude extracts. The methanolic extracts were tested against NBT-T2 cell line. The assay result showed that 8.5 %, 29.2 % and 46.2 % of the extract have activity against the cell line at 0.1, 1.0 and 10.0 μg/mL. While, a 16.0 % of the extract did not showed activity against the cell line.