The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

Natural Products and Bioprospecting

Xu-Dong Zhao¹  Ya-Ping Liu²  Xiao-Dong Luo²  Zi-Ru Yan²  Bei Wang²  Xin Wei²  Pei-Feng Zhu²  Hao-Fei Yu²  Zhi Dai³ 

[1] Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences;University of Chinese Academy of Sciences;

关键词: Lycium barbarum;    Phenolic amides;    Anticancer activities;    Glioma stem cell;   

DOI  :  10.1007/s13659-017-0134-x

来源: DOAJ

【 摘 要 】

Abstract Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines. Graphical Abstract

【 授权许可】

Unknown