Epigenetic dysregulation in glioma

Cancer Science

Yutaka Kondo²  Keisuke Katsushima²  Fumiharu Ohka²  Atsushi Natsume¹ 

[1]Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan

[2]Division of Epigenomics, Aichi Cancer Center Research Institute, Nagoya, Japan

关键词: Glioma stem cell;    DNA methylation;    epigenetics;    histone modification;    non‐coding RNA;   

DOI  :  10.1111/cas.12379

来源: Wiley

【 摘 要 】

Abstract

Given that treatment options for patients with glioblastoma are limited, much effort has been made to clarify the underlying mechanisms of gliomagenesis. Recent genome-wide genomic and epigenomic analyses have revealed that mutations in epigenetic modifiers occur frequently in gliomas and that dysregulation of epigenetic mechanisms is closely associated with glioma formation. Given that epigenetic changes are reversible, understanding the epigenetic abnormalities that arise in gliomagenesis might be key to developing more effective treatment strategies for glioma. In this review, we focus on the recent advancements in epigenetic research with respect to gliomas, consider how epigenetic mechanisms dynamically regulate tumor cells, including the cancer stem cell population, and discuss perspectives and challenges for glioma treatment in the near future.

【 授权许可】

CC BY-NC-ND   
© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.