Development of therapeutic systems to treat the infarcted heart

Myocardial infarction;Cardiac protection;Cardiac regeneration;Angiogenesis;Therapeutic system;Nanoparticle;Dendrimer;Exosome;Hypoxia;N-acetylglucosamine

Gray, Warren Dale ; Luo, Ying Davis, Michael E. Biomedical Engineering (Joint GT/Emory Department) Jo, Hanjoong Searles, Charles Champion, Julie A. ; Luo, Ying

University:Georgia Institute of Technology

Department:Biomedical Engineering (Joint GT/Emory Department)

关键词: Myocardial infarction;    Cardiac protection;    Cardiac regeneration;    Angiogenesis;    Therapeutic system;    Nanoparticle;    Dendrimer;    Exosome;    Hypoxia;    N-acetylglucosamine;   

Others  :  https://smartech.gatech.edu/bitstream/1853/53429/1/GRAY-DISSERTATION-2014.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

Cardiovascular disease is the leading cause of morbidity and mortality in developed nations, and heart disease is predicted to remain the leading killer for the foreseeable future. Acute myocardial infarctions—nearly 1.1 million annually occurring in the U.S. alone—are the major cardiovascular disease subgroup. Current treatments for myocardial infarction are limited to interventions that serve to mitigate the initial insult, but clinical applications to protect or regenerate damaged myocardium are lacking. This dissertation examines three therapeutic systems to treat the infarcted heart. First, the decoration of a polymeric nanoparticle with N-acetylglucosamine for the uptake of anti-­apoptotic therapeutics to ameliorate cardiomyocyte cell death. Second, novel dendrimeric structure architecture to allow for regio­selected decoration of ligands to induce angiogenesis. Third, exosomes secreted from hypoxic cardiac progenitor cells as a naturally derived therapeuticfor angiogenesis and anti-fibrosis, and to provide bio-inspired clues for future therapies.