Numerical modelling of the influence of stromal cells on tumor growth and angiogenesis

8th TSME-International Conference on Mechanical Engineering

Sakiyama, Nobuyuki^1 ; Nagayama, Katsuya^1

Department of Mechanical Information Science and Technology, Kyushu Institute of Technology, 680-4 Kawazu, Fukuoka, Iizuka

820-8502, Japan^1

关键词: Angiogenesis;    Benign tumor;    Efficient detection;    Growth process;    Malignant tumors;    Stromal cells;    Tumor growth;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/297/1/012021/pdf
DOI  :  10.1088/1757-899X/297/1/012021

来源: IOP

【 摘 要 】

According to the statistics provided by the Ministry of Health, Labor and Welfare the death of one in 3.5 Japanese people is attributed to tumor highlighting the need for active research on malignant tumors. Early detection can be cited as a countermeasure against malignant tumors, but it is often difficult to observe the growth process, and thorough understanding of the phenomena will aid in more efficient detection of such tumors. A malnourished benign tumor may create new blood vessels from existing ones and proliferate abnormally by absorbing nutrients from these newly created blood vessels to become malignant. Different factors influence the shape of tumors and shape is an important factor in evaluating their malignancy. Because interstitial cells greatly influence tumor growth, investigating the influence of stromal cells on tumor growth will help in developing a better understanding of the phenomenon.