Hyaluronan and cardiac regeneration

Journal of Biomedical Science

Claudio Muscari²  Carlo Guarnieri²  Claudio Marcello Caldarera²  Emanuele Giordano²  Marco Govoni¹  Francesca Bonafè² 

[1] BioEngLab, Health Science and Technology, Interdepartmental Center for Industrial Research (HST-CIRI), University of Bologna, Ozzano Emilia, Italy;National Institute for Cardiovascular Research (INRC), Bologna, Italy

关键词: Adult stem cells;    Cardiac regeneration;    Myocardial infarction;    Hyaluronan;   

Others  :  1146118
DOI  :  10.1186/s12929-014-0100-4

 received in 2014-08-06, accepted in 2014-10-16,  发布年份 2014

【 摘 要 】

Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations. In the heart HA is involved in physiological functions, such as cardiac development during embryogenesis, and in pathological conditions including atherosclerosis and myocardial infarction. Moreover, owing to its relevant biological properties, HA has been widely used as a biomaterial for heart regeneration after a myocardial infarction. Indeed, HA and its derivatives are biodegradable and biocompatible, promote faster healing of injured tissues, and support cells in relevant processes including survival, proliferation, and differentiation. Injectable HA-based therapies for cardiovascular disease are gaining growing attention because of the benefits obtained in preclinical models of myocardial infarction. HA-based hydrogels, especially as a vehicle for stem cells, have been demonstrated to improve the process of cardiac repair by stimulating angiogenesis, reducing inflammation, and supporting local and grafted cells in their reparative functions. Solid-state HA-based scaffolds have been also investigated to produce constructs hosting mesenchymal stem cells or endothelial progenitor cells to be transplanted onto the infarcted surface of the heart. Finally, applying an ex-vivo mechanical stretching, stem cells grown in HA-based 3D scaffolds can further increase extracellular matrix production and proneness to differentiate into muscle phenotypes, thus suggesting a potential strategy to create a suitable engineered myocardial tissue for cardiac regeneration.

【 授权许可】

   
2014 Bonafè et al.; licensee BioMed Central Ltd.

【 图 表 】

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