Novel strategies for cardiac drug delivery

Cardiac dysfunction;Myocardial infarction;Necrosis;Hoechst;Nitrilotriacetic acid;Polyketals;Biomaterials;Heart disease;Drug delivery

Sy, Jay Christopher ; Biomedical Engineering

University:Georgia Institute of Technology

Department:Biomedical Engineering

关键词: Cardiac dysfunction;    Myocardial infarction;    Necrosis;    Hoechst;    Nitrilotriacetic acid;    Polyketals;    Biomaterials;    Heart disease;    Drug delivery;   

Others  :  https://smartech.gatech.edu/bitstream/1853/39531/1/sy_jay_c_201105_phd.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

The American Heart Association (AHA) estimates that at least one American will die from a coronary event every minute, costing over $150 billion in 2008 alone.Regenerating the myocardium of patients that survive the initial infarction has proven to be an elusive goal.A variety of factors - including the loss of contractile cells, inflammatory response following infarction, cardiac hypertrophy, and lack of suitable cues for progenitor cells - causes fibrosis in the heart and loss of cardiac function.This dissertation examines three drug delivery strategies aimed at improving conditions for cardiac regeneration: polyketal microspheres as non-inflammatory drug delivery vehicles; surface functionalization of microparticles with nitrilotriacetic acid-nickel (NTA-Ni) for non-covalent tethering of proteins; and using Hoechst-inspired ligands for targeting extracellular DNA in necrotic tissue.