JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 卷:127 |
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases | |
Article | |
Akdis, Muebeccel1  Burgler, Simone1  Crameri, Reto1  Eiwegger, Thomas1  Fujita, Hiroyuki1  Gomez, Enrique1  Klunker, Sven1  Meyer, Norbert1  O'Mahony, Liam1  Palomares, Oscar1  Rhyner, Claudio1  Quaked, Nadia1  Schaffartzik, Anna1  Van De Veen, Willem1  Zeller, Sabine1  Zimmermann, Maya1  Akdis, Cezmi A.1  | |
[1] Univ Zurich, Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland | |
关键词: Cytokines; interleukins; T cells; B cells; dendritic cells; adaptive immune response; humoral immune response; allergy and asthma; | |
DOI : 10.1016/j.jaci.2010.11.050 | |
来源: Elsevier | |
【 摘 要 】
Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among T-H and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-gamma. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections. (J Allergy Clin Immunol 2011;127:701-21.)
【 授权许可】
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