开放图书详细信息
Frontiers Research Topics | ||
The Evolution and Development of the Antibody Repertoire | ||
Harry W Schroeder Jr | ||
keywords: immunoglobulin; B cells; sequence analysis software; Antibody repertoire; comparative immunology; natural antibodies; | ||
Publisher: Frontiers Media SA | ||
Subject: |
【 摘 要 】
Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes.【 授权许可】
CC BY
Copyright 2007-2040 Frontiers Media SA. All rights reserved. All content included on this site, such as text, graphics, logos, button icons, images, video/audio clips, downloads, data compilations and software, is the property of or is licensed to.All copyright, and all rights therein, are protected by national and internation.The above represents a summary only. For the full conditions see the Conditions for Authors and the Conditions for Website Use.
Files | Size | Format | View |
---|---|---|---|
The Evolution and Development of the Antibody Repertoire.jpg | 6KB | Image | download |
The Evolution and Development of the Antibody Repertoire.PDF | 16999KB | Image | download |
【 图 表 】
The Evolution and Development of the Antibody Repertoire.PDF
The Evolution and Development of the Antibody Repertoire.jpg