Compare the Difference of B-cell Epitopes of EgAgB1 and EgAgB3 Proteins Selected through Bioinformatic Analysis

5th Annual International Conference on Material Science and Environmental Engineering

材料科学;生态环境科学

An, Mengting^1 ; Zhang, Fengbo^1 ; Zhu, Yuejie^1 ; Zhao, Xiao^1 ; Ding, Jianbing^1

XinJiang Medical University, Urumqi, Xinjiang

830011, China^1

关键词: Amino acid residues;    B cells;    Bioinformatic analysis;    Bioinformatics software;    Cystic echinococcosis;    Early diagnosis;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/301/1/012019/pdf
DOI  :  10.1088/1757-899X/301/1/012019

来源: IOP

【 摘 要 】

Cystic echinococcosis, as a zoonosis, seriously endangers humans and animals, so early diagnosis of this disease is particularly important. Therefore, this study is to predict B-cell epitopes of EgAgB1 and EgAgB3 proteins by bioinformatics software. B-cell epitopes of EgAgB1 and EgAgB3 proteins are predicted using DNAStar and IEDB software. The results suggest that there are two potential B-cell epitopes in EgAgB1, which located in the 8-15 and 31-37 amino acid residue segments. And two potential B-cell epitopes in EgAgB2, located in the 20∼27 and 47∼53 amino acid residue segments. This study predicted the B-cell epitopes of EgAgB1 and EgAgB3 proteins, which laid the foundation for the early diagnosis of Cystic echinococcosis.