Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:138

Review

Akdis, Mubeccel¹  Aab, Alar¹  Altunbulakli, Can¹  Azkur, Kursat¹  Costa, Rita A.¹  Crameri, Reto¹  Duan, Su¹  Eiwegger, Thomas¹  Eljaszewicz, Andrzej¹  Ferstl, Ruth¹  Frei, Remo¹  Garbani, Mattia¹  Globinska, Anna¹  Hess, Lena¹  Huitema, Carly¹  Kubo, Terufumi¹  Komlosi, Zsolt¹  Konieczna, Patricia¹  Kovacs, Nora¹  Kucuksezer, Umut C.¹  Meyer, Norbert¹  Morita, Hideaki¹  Olzhausen, Judith¹  O'Mahony, Liam¹  Pezer, Marija¹  Prati, Moira¹  Rebane, Ana¹  Rhyner, Claudio¹  Rinaldi, Arturo¹  Sokolowska, Milena¹  Stanic, Barbara¹  Sugita, Kazunari¹  Treis, Angela¹  van de Veen, Willem¹  Wanke, Kerstin¹  Wawrzyniak, Marcin¹  Wawrzyniak, Paulina¹  Wirz, Oliver F.¹  Zakzuk, Josefina Sierra¹  Akdis, Cezmi A.¹ 

[1] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, CH-8006 Zurich, Switzerland

关键词: Cytokines;    interleukins;    T cells;    B cells;    dendritic cells;    innate immune response;    adaptive immune response;    humoral immune response;    allergy and asthma;   

DOI  :  10.1016/j.jaci.2016.06.033

来源: Elsevier

【 摘 要 】

There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-alpha, and TGF-beta offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors. More than 60 cytokines have been designated as interleukins since the initial discoveries of monocyte and lymphocyte interleukins (called IL-1 and IL-2, respectively). Studies of transgenic or gene-deficient mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided essential information about their functions. Here we review recent developments on IL-1 to IL-38, TNF-alpha, TGF-beta, and interferons. We highlight recent advances during the last few years in this area and extensively discuss their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases.

【 授权许可】

Free