Biosensors as a future diagnostic approach for COVID-19

LIFE SCIENCES

卷:273

Review

Abid, Suhad Abbas¹  Muneer, Ahmed Ahmed^2,10  Al-Kadmy, Israa M. S.^3,4  Sattar, Anas A.⁵  Beshbishy, Amany Magdy⁶  Batiha, Gaber El-Saber⁷  Hetta, Helal F.^8,9 

[1] Mustansiriyah Univ, Coll Sci, Dept Biol, Branch Microbiol, POX 10244, Baghdad, Iraq

[2] Plymouth Univ, Fac Sci & Engn, Sch Comp Elect & Math, Wolfson Nanomat & Devices Lab, Plymouth PL4 8AA, Devon, England

[3] Mustansiriyah Univ, Coll Sci, Dept Biol, Branch Biotechnol, POX 10244, Baghdad, Iraq

[4] Univ Plymouth, Fac Sci & Engn, Sch Engn, Plymouth PL4 8AA, Devon, England

[5] Univ Plymouth, Sch Biomed & Healthcare Sci, Peninsula Sch Med & Dent, Plymouth, Devon, England

[6] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Nishi 2-13,Inada Cho, Obihiro, Hokkaido 0808555, Japan

[7] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Egypt

[8] Assiut Univ, Fac Med, Dept Med Microbiol & Immunol, Assiut, Egypt

[9] Univ Cincinnati, Coll Med, Dept Internal Med, Cincinnati, OH USA

[10] Univ Mosul, Coll Sci, Dept Phys, Mosul, Iraq

关键词: COVID-19;    Rapid detection;    Viral biosensor;    Bioreceptors;    Electrochemical;    SPR;    SARS-CoV-2;    Spike proteins;    ACE2 receptors;   

DOI  :  10.1016/j.lfs.2021.119117

来源: Elsevier

【 摘 要 】

Biosensors are important devices in clinical diagnostics, food processing, and environmental monitoring for detecting various analytes, especially viruses. These biosensors provide rapid and effective instruments for qualitative and quantitative detection of infectious diseases in real-time. Here, we report the development of biosensors based on various techniques. Additionally, we will explain the mechanisms, advantages, and disadvantages of the most common biosensors that are currently used for viral detection, which could be optical (e.g., surface-enhanced Raman scattering (SERS), Surface plasmon resonance (SPR)) and electrochemical biosensors. Based on that, this review recommends methods for efficient, simple, low-cost, and rapid detection of SARS-CoV-2 (the causative agent of COVID-19) that employ the two types of biosensors depending on attaching hemoglobin beta-chain and binding of specific antibodies with SARS-CoV-2 antigens, respectively.

【 授权许可】

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