期刊论文详细信息
NEUROBIOLOGY OF DISEASE 卷:128
Bottom-up gamma maintenance in various disorders
Review
Garcia-Rill, E.1  Mahaffey, S.1  Hyde, James R.2  Urbano, F. J.3 
[1] Univ Arkansas Med Sci, Ctr Translat Neurosci, Little Rock, AR 72205 USA
[2] Univ Pittsburgh, Pittsburg, KS USA
[3] Univ Buenos Aires, IFIBYNE CONICET UBA, DFBMC, Buenos Aires, DF, Argentina
关键词: Alzheimer's disease;    Bipolar disorder;    Bottom-up gamma;    Coma;    Depression;    Mesencephalic locomotor region;    Neglect;    Parkinson's disease;    Pedunculopontine nucleus;    Reticular activating system;    Schizophrenia;    Top-down beta;   
DOI  :  10.1016/j.nbd.2018.01.010
来源: Elsevier
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【 摘 要 】

Maintained gamma band activity is a key element of higher brain function, participating in perception, executive function, and memory. The pedunculopontine nucleus (PPN), as part of the reticular activating system (RAS), is a major source of the bottom-up flow of gamma activity to higher regions. However, interruption of gamma band activity is associated with a number of neurological and psychiatric disorders. This review will focus on the role of the PPN in activating higher regions to induce arousal and descending pathways to modulate posture and locomotion. As such, PPN deep brain stimulation (DBS) can not only help regulate arousal and stepping, but continuous application may help maintain necessary levels of gamma band activity for a host of other brain processes. We will explore the potential future applications of PPN DBS for a number of disorders that are characterized by disturbances in gamma band maintenance.

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