Bottom-up gamma maintenance in various disorders

Neurobiology of Disease

S. Mahaffey¹  E. Garcia-Rill²  James R. Hyde²  F.J. Urbano³ 

[1]Corresponding author at: Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Slot 847, 4301 West Markham St., Little Rock, AR 72205, USA.

[2]Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USA

[3]University of Pittsburgh, Pittsburgh, PA, USA

关键词: Alzheimer's disease;    Bipolar disorder;    Bottom-up gamma;    Coma;    Depression;    Mesencephalic locomotor region;   

DOI  :  

来源: DOAJ

【 摘 要 】

Maintained gamma band activity is a key element of higher brain function, participating in perception, executive function, and memory. The pedunculopontine nucleus (PPN), as part of the reticular activating system (RAS), is a major source of the “bottom-up” flow of gamma activity to higher regions. However, interruption of gamma band activity is associated with a number of neurological and psychiatric disorders. This review will focus on the role of the PPN in activating higher regions to induce arousal and descending pathways to modulate posture and locomotion. As such, PPN deep brain stimulation (DBS) can not only help regulate arousal and stepping, but continuous application may help maintain necessary levels of gamma band activity for a host of other brain processes. We will explore the potential future applications of PPN DBS for a number of disorders that are characterized by disturbances in gamma band maintenance.

【 授权许可】

Unknown