The Critical Role of Intrinsic Membrane Oscillations

Neuro-signals

Sang-Hun Lee^1,2¹  Francisco J. Urbano^1,3²  Edgar Garcia-Rill^1³ 

[1] Center for Translational Neuroscience^1;Department of Neurology,University of Arkansas for Medical Sciences, Little Rock, AR, USA^2;IFIBYNE, University of Buenos Aires, Buenos Aires, Argentina^3

关键词: Bottom-up gamma;    N-type channel;    Parafascicular nucleus;    Pedunculopontine nucleus;    P/Q-type channel;    Subcoeruleus nucleus;   

DOI  :  10.1159/000493900

学科分类：神经科学

来源: S Karger AG

【 摘 要 】

Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and “binding”, problem solving, memory, waking, and rapid eye movement (REM) sleep.

【 授权许可】

CC BY-NC-ND