The involvement of Reelin in neurodevelopmental disorders

NEUROPHARMACOLOGY

卷:68

Review

Folsom, Timothy D.¹  Fatemi, S. Hossein^1,2,3 

[1] Univ Minnesota, Sch Med, Dept Psychiat, Div Neurosci Res, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA

关键词: Reelin;    Schizophrenia;    Autism;    Bipolar disorder;    Major depression;    Lissencephaly;    Alzheimer's disease;    Treatment;   

DOI  :  10.1016/j.neuropharm.2012.08.015

来源: Elsevier

【 摘 要 】

Reelin is a glycoprotein that serves important roles both during development (regulation of neuronal migration and brain lamination) and in adulthood (maintenance of synaptic function). A number of neuropsychiatric disorders including autism, schizophrenia, bipolar disorder, major depression, Alzheimer's disease and lissencephaly share a common feature of abnormal Reelin expression in the brain. Altered Reelin expression has been hypothesized to impair neuronal connectivity and synaptic plasticity, leading ultimately to the cognitive deficits present in these disorders. The mechanisms for abnormal Reelin expression in some of these disorders are currently unknown although possible explanations include early developmental insults, mutations, hypermethylation of the promoter for the Reelin gene (RELN), miRNA silencing of Reelin mRNA, FMRP underexpression and Reelin processing abnormalities. Increasing Reelin expression through pharmacological therapies may help ameliorate symptoms resulting from Reelin deficits. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free