Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:27

Article

Peng, Bo¹  Liu, Chunrong¹  Li, Zhen²  Day, Jacob J.¹  Lu, Yun³  Lefer, David J.²  Xian, Ming¹ 

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Cardiovasc Ctr Excellence, New Orleans, IA 70112 USA

[3] Southern Illinois Univ Edwardsville, Dept Chem, Edwardsville, IL 62026 USA

关键词: Ammonium tetrathiomolybdate;    Hydrogen sulfide;    Donor;    Oxidative damage;   

DOI  :  10.1016/j.bmcl.2016.12.023

来源: Elsevier

【 摘 要 】

Here we report the model studies of the reactions between NADH models (using HEH and BNAH) and sulfane sulfurs (using polysulfides). Such reactions could lead to the oxidation of NADH models and the production of hydrogen sulfide (H2S). Kinetics of the reaction between BNAH and elemental sulfur S-8 were determined in ethanol and the second-order rate constant was found to be 0.074 M-1 min(-1) (at 37 degrees C) suggesting this is a slow process. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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