Ammonium tetrathiomolybdate as a water-soluble and slow-release hydrogen sulfide donor

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:26

Article

Xu, Shi¹  Yang, Chun-Tao²  Meng, Fu-Hui²  Pacheco, Armando¹  Chen, Li²  Xian, Ming¹ 

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

[2] Guangzhou Med Univ, Dept Physiol, Guangzhou 511436, Guangdong, Peoples R China

关键词: Ammonium tetrathiomolybdate;    Hydrogen sulfide;    Donor;    Oxidative damage;   

DOI  :  10.1016/j.bmcl.2016.02.005

来源: Elsevier

【 摘 要 】

Ammonium tetrathiomolybdate (TTM) was found to be a slow hydrogen sulfide (H2S) releasing agent. Its H2S generation capability in aqueous solutions was confirmed by UV-vis and fluorescence assays. TTM also showed H2S-like cytoprotective effects in hydrogen peroxide (H2O2)-induced oxidative damage in HaCaT cells. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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