Effect of Ampicillin wastewater on the T-AOC and LDH activities of Zebrafish

2019 5th International Conference on Energy Materials and Environment Engineering

能源学;生态环境科学

Wang, Yaxue^1^2 ; Wu, Pengpeng^1^2 ; Shen, Hong-Yan^1^2

College of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang, China^1

Pharmaceutical Molecular Chemistry Laboratory of Hebei Province, Shijiazhuang, China^2

关键词: Antioxidative capacity;    Change trends;    Ecotoxicity;    Indoor exposure;    Lactate dehydrogenase;    Muscle tissues;    Oxidative damage;    Sharp increase;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/295/2/012018/pdf
DOI  :  10.1088/1755-1315/295/2/012018

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

In order to define eco-toxicity effect of Ampicillin wastewater on zebrafish, the indoor exposure method was used to study the impact of Ampicillin wastewater on zebrafish. In this study, zebrafish was exposed to ampicillin wastewater of 0.5%, 1.0%, 1.5% and 2.0% groups for 15 days to study the effect of T-AOC (Total Antioxidative Capacity) and LDH (Lactate Dehydrogenase) activities. According to the experimental data, the T-AOC and LDH activities in zebrafish muscle tissue had changed significantly during the period of exposure. The experimental results showed that the T-AOC value of zebrafish in each exposed group showed a "Λ" type change trend. On the 6th day, the 2.0% exposed group reached the maximum value of the whole test period (6.5399U•mg-1). The change of LDH activity was similar to that of T-AOC activity, showing a trend of "sharp increase - decline". Among them, on the 12th day, the 1% exposed group reached the maximum (792.28 U•mg-1). The research shows ampicillin wastewater can cause some degree of oxidative damage to zebrafish.