Influence of diabetes on cardiac resynchronization therapy in heart failure patients: a meta-analysis

BMC Cardiovascular Disorders

Research Article

Xuejing Zhang¹  Li Liu¹  Xiuping Bi¹  Hui Sun¹  Guohai Su¹  Hui Song¹  Yuqing Guan¹  Hong Lv¹  Huating Wang¹  Min Wei¹  Lei Wang¹  Yong Zhao² 

[1] Department of Cardiology, Jinan Central Hospital, Affiliated with Shandong University, 250013, Jinan, Shandong Province, China;Department of Geriatric Cardiology, Provincial Hospital Affiliated with Shandong University, 250021, Jinan, Shandong Province, China;

关键词: Cardiac resynchronization therapy;    Diabetes mellitus;    Heart failure;    Outcome;    All-cause mortality;   

DOI  :  10.1186/s12872-015-0018-0

 received in 2014-08-24, accepted in 2015-02-27,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundDiabetes mellitus is an independent risk factor of increased morbidity and mortality in patients with heart failure. Cardiac resynchronization therapy (CRT), a pacemaker-based therapy for dyssynchronous heart failure, improves cardiac performance and quality of life, but its effect on mortality in patients with diabetes is uncertain.MethodsWe performed a meta-analysis of results from randomized controlled trials (RCTs) of the long-term outcome of cardiac resynchronization therapy for heart failure in diabetic and non-diabetic patients. Literature search of MEDLINE via Pubmed for reports of randomized controlled trials of Cardiac resynchronization for chronic symptomatic left-ventricular dysfunction in patients with and without diabetes mellitus, with death as the outcome. Relevant data were analyzed by use of a random-effects model. Reports published from 1994 to 2011 that described RCTs of CRT for treating chronic symptomatic left ventricular dysfunction in patients with and without diabetes, with all-cause mortality as an outcome.ResultsA total of 5 randomized controlled trials met the inclusion criteria, for 2,923 patients. The quality of studies was good to moderate. Cardiac resynchronization significantly reduced the mortality for heart failure patients with or without diabetes mellitus. Mortality was 24.3% for diabetic patients with heart failure and 20.4 % for non-diabetics (odds ratio 1.28, 95% confidence interval 1.06–1.55; P = 0.010).ConclusionsCardiac resynchronization therapy (CRT) may reduce mortality from progressive heart failure in patients with or without diabetes mellitus, but mortality may be higher for patients with than without diabetes after CRT for heart failure.

【 授权许可】

CC BY   
© Sun et al. 2015