Antibacterial activity of some selected medicinal plants of Pakistan

BMC Complementary and Alternative Medicine

Research Article

Muhammad Zia¹  Sobia Nisa²  Yamin Bibi²  Fayyaz M Chaudhary² 

[1] Department of Biotechnology, Quaid-i-Azam University Islamabad, 45320, Pakistan;Department of Microbiology, Quaid-i-Azam University, 45320, Islamabad, Pakistan;

关键词: Crude Extract;    Plant Extract;    Bacillus Subtilis;    American Type Culture Collection;    Berberine;   

DOI  :  10.1186/1472-6882-11-52

 received in 2011-02-21, accepted in 2011-06-30,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundScreening of the ethnobotenical plants is a pre-requisite to evaluate their therapeutic potential and it can lead to the isolation of new bioactive compounds.MethodsThe crude extracts and fractions of six medicinal important plants (Arisaema flavum, Debregeasia salicifolia, Carissa opaca, Pistacia integerrima, Aesculus indica, and Toona ciliata) were tested against three Gram positive and two Gram negative ATCC bacterial species using the agar well diffusion method.ResultsThe crude extract of P. integerrima and A. indica were active against all tested bacterial strains (12-23 mm zone of inhibition). Other four plant's crude extracts (Arisaema flavum, Debregeasia salicifolia, Carissa opaca, and Toona ciliata) were active against different bacterial strains. The crude extracts showed varying level of bactericidal activity. The aqueous fractions of A. indica and P. integerrima crude extract showed maximum activity (19.66 and 16 mm, respectively) against B. subtilis, while the chloroform fractions of T. ciliata and D. salicifolia presented good antibacterial activities (13-17 mm zone of inhibition) against all the bacterial cultures tested.ConclusionThe methanol fraction of Pistacia integerrima, chloroform fractions of Debregeasia salicifolia & Toona ciliata and aqueous fraction of Aesculus indica are suitable candidates for the development of novel antibacterial compounds.

【 授权许可】

Unknown   
© Bibi et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.