Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts

Malaria Journal

Reviews

Hagai Ginsburg¹  Eric Deharo² 

[1] Department of Biological Chemistry, Institut of Life Sciences, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel;Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR 152, UPS, Université de Toulouse, 118 Route de Narbonne, F-31062, Toulouse cedex 9, France;Institut de Recherche pour le Développement, UMR 152, Mission IRD casilla, 18-1209, Lima, Peru;

关键词: Malaria;    Active Compound;    Crude Extract;    Plant Extract;    Plasmodium Falciparum;   

DOI  :  10.1186/1475-2875-10-S1-S5

来源: Springer

【 摘 要 】

In the search for antimalarials from ethnobotanical origin, plant extracts are chemically fractionated and biological tests guide the isolation of pure active compounds. To establish the responsibility of isolated active compound(s) to the whole antiplasmodial activity of a crude extract, the literature in this field was scanned and results were analysed quantitatively to find the contribution of the pure compound to the activity of the whole extract. It was found that, generally, the activity of isolated molecules could not account on their own for the activity of the crude extract. It is suggested that future research should take into account the “drugs beside the drug”, looking for those products (otherwise discarded along the fractionation process) able to boost the activity of isolated active compounds.

【 授权许可】

CC BY   
© Deharo and Ginsburg; licensee BioMed Central Ltd. 2011