Annotation of the Clostridium Acetobutylicum Genome

Daly, M. J.

Henry M. Jackson Foundation (United States)

关键词: Clostridium Acetobutylicum;    Chromosomes;    Forecasting;    Genes;    Bacillus Subtilis;   

DOI  :  10.2172/830021
RP-ID  :  FG02-00ER62924
RP-ID  :  830021

美国|英语

来源: UNT Digital Library

【 摘 要 】

The genome sequence of the solvent producing bacterium Clostridium acetobutylicum ATCC824, has been determined by the shotgun approach. The genome consists of a 3.94 Mb chromosome and a 192 kb megaplasmid that contains the majority of genes responsible for solvent production. Comparison of C. acetobutylicum to Bacillus subtilis reveals significant local conservation of gene order, which has not been seen in comparisons of other genomes with similar, or, in some cases, closer, phylogenetic proximity. This conservation allows the prediction of many previously undetected operons in both bacteria.