Epidemiology of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) among a cohort of HIV-infected and uninfected Ghanaian women

BMC Cancer

Research Article

Yaw Adu-Sarkodie¹  Mohamed Mutocheluh¹  Philippe Mayaud²  Dorcas Obiri-Yeboah³  Daniel Amoako-Sakyi³  Gloria Allornuvor⁴  Patrick K. Akakpo⁵  Emmanuel Adjei-Danso⁶ 

[1] Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK;Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana;Department of Obstetrics and Gynaecology, Cape Coast Teaching Hospital, Cape Coast, Ghana;Department of Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana;Mineworkers Union of Trade Union Congress, Tarkwa, Ghana;

关键词: Human papillomavirus (HPV);    Genotyping;    Squamous intraepithelial lesions (SIL);    Cervical cancer;    Human immunodeficiency virus (HIV);    Ghana;   

DOI  :  10.1186/s12885-017-3682-x

 received in 2016-10-04, accepted in 2017-10-10,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThere is limited data in Ghana on the epidemiology of HPV and cervical neoplasia and their associations with HIV. This study aimed to compare among HIV-1 seropositive and HIV-seronegative Ghanaian women: (1) the prevalence, genotype distribution and risk factors associated with cervical HPV infection; and (2) the prevalence and risk factors associated with abnormal cervical cytology.MethodsA comparative frequency-matched study was conducted in a systematic sample of women aged ≥18 years attending HIV and general outpatient clinics in Cape Coast Teaching Hospital, Ghana. Participants were interviewed and cervical samples collected for HPV genotyping (Seegene Anyplex-II HPV28) and cytological testing.ResultsOverall, 333 women were recruited, 163 HIV-1 seropositive and 170 HIV-seronegative women of mean age 43.8 years (SD ±9.4)) and 44.3 years (SD ±12.8), respectively. The prevalence of 14 high-risk (hr) HPV genotypes was higher among HIV-1 seropositive women (65.6% vs. 30.2%, P < 0.0001), as was proportion with multiple hr.-HPV infections (60.6% vs. 21.3%, P < 0.0001). HPV35 was the most prevalent hr.-HPV genotype in both groups (11.9% and 5.3%). The main factors associated with hr.-HPV infection were age for HIV-positive women and circumcision status of main sexual partner for both HIV-negative and positive women.Abnormal cervical cytology prevalence was higher among HIV-1 seropositive women (any SIL: 14.1% vs. 1.2%, P < 0.0001; low-grade SIL [LSIL]: 4.9% vs. 0.6%, P = 0.02; high-grade SIL: 1.8% vs. 0%, P = 0.07). Among HIV-1 seropositive women, number of pregnancies and CD4+ cell count were associated with LSIL+ cytology. There was strong association between LSIL+ abnormalities and HPV35 (aOR = 4.7, 95%CI: 1.3–17.7, P = 0.02).ConclusionsHIV-1 infected women bear significant burden of HPV infection and related disease. Prevention and screening programmes should be specifically deployed for this population in Ghana.

【 授权许可】

CC BY   
© The Author(s). 2017