Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study

BMC Infectious Diseases

Ai-Hua Sun¹  Jie Yan²  Lei Ji¹  Yue-Ping Yu¹  Xing-Li Fan¹  Xiao-Xiang Liu¹ 

[1] Faculty of Basic Medicine, Zhejiang Medical College, Hangzhou 310053, Zhejiang, P. R. China;Department of Medical Microbiology and Parasitology, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, P. R. China

关键词: Cytology;    Genotyping;    Prevalence;    Human papillomavirus (HPV);   

Others  :  1090397
DOI  :  10.1186/s12879-014-0708-8

 received in 2014-08-21, accepted in 2014-12-11,  发布年份 2014

【 摘 要 】

Background

Human papillomavirus (HPV) infection is the main etiological factor for cervical cancer and premalignant lesions of the cervix. The purposes of the present study were to determine the prevalence of type-specific HPV infections and the association of different HPV types with cervical dysplasia among women in Zhejiang province, Southeast China.

Methods

A total of 15,267 women presenting to a gynaecological outpatient clinic were enrolled in this study. Women were screened for HPV in addition to routine cervical cytology testing. Microarray hybridization and liquid-based cytology tests were used to detect HPV genotypes and cervical cytology, respectively.

Results

Based on the population attending a gynaecological outpatient clinic, overall prevalence of any 23 HPV type was 22.8% and multiple HPV infection was found in 4.0% of all the outpatients. HPV prevalence showed bimodal age distribution, with a peak (55.7%) at the ≤20 age group and a second one (35.5%) at >60 age group. In total samples, the five most frequent types were HPV 16 (4.4%), 58 (2.9%), 52 (2.7%), 33 (2.2%) and 11 (1.9%). Overall HPV prevalence increased with the severity of the cytologic result. Analysis through crude odds ratios (ORs) revealed that the cervical lesion risk of HPV-infected women increased to about 26-fold of uninfected women (OR 26.1, 95% CI 22.4 to 30.3). The five most risky HPV types associated with abnormal cytology were HPV 73, 16, 82, 45 and 51.

Conclusions

This study provided baseline data on HPV prevalence in women attending a gynecological outpatient clinic in Zhejiang province. Our data will supply guidance for the primary screening and vaccination program for cervical cancer in this area.

【 授权许可】

   
2014 Liu et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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