Disseminated Talaromyces marneffei and Mycobacterium intracellulare coinfection in an HIV-infected patient

International Journal of Infectious Diseases

Young Hee Eun¹  Hyeri Seok¹  Inseub Shin¹  Seung-Eun Lee¹  You-Bin Lee¹  Jae-Hoon Ko²  Kyong Ran Peck² 

[1] Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea;Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea;

关键词: Talaromyces marneffei;    Mycobacterium intracellulare;    HIV;    Lymphadenopathy;    Coinfection;   

DOI  :  10.1016/j.ijid.2015.07.020

来源: DOAJ

【 摘 要 】

A 25-year-old man with human immunodeficiency virus (HIV) infection presented with fever that had lasted 1 month. The CD4+ T lymphocyte count was 7 cells/μL and computed tomography showed several small lung nodules, splenomegaly, and multiple lymphadenopathy. Talaromyces marneffei was isolated in the initial blood cultures. As the fever persisted despite clearance of fungemia and 10 days of liposomal amphotericin B treatment, cervical lymph node fine-needle aspiration was performed. Mycobacterium intracellulare was isolated from sputum and neck node aspiration cultures. The patient was successfully treated with liposomal amphotericin B, clarithromycin, and ethambutol in addition to antiretroviral therapy. This case suggests that we should consider coinfection of opportunistic pathogens in febrile immunosuppressed patients if the patient does not respond properly to the initial treatment.

【 授权许可】

Unknown