Cutaneous penicilliosis due to penicillium marneffei infection in human immunodeficiency virus infected patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Karo, F.A.^1,2 ; Kembaren, T.^1,2 ; Saragih, R.^1,2 ; Sembiring, E.^1,3 ; Ginting, F.^1,2 ; Ginting, Y.^1,2

Division of Tropical Medicine and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Haji Adam Malik General Hospital, Medan, Indonesia^2

Dr.Pirngadi General Hospital, Medan, Indonesia^3

关键词: CD4+T-lymphocytes;    General hospitals;    Human immunodeficiency virus;    Infected patients;    Itraconazole;    Lymphadenopathy;    Physical examinations;    Southeast Asia;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012060/pdf
DOI  :  10.1088/1755-1315/125/1/012060

来源: IOP

【 摘 要 】

Penicillium marneffei is an important cause of morbidity and mortality in HIV-infected and other immunosuppressed. The diagnosis of penicilliosis should be considered in patients who live in or are from Southeast Asia who present with fever, weight loss, nonproductive cough, skin lesions, hepatosplenomegaly, and/or generalized lymphadenopathy. Cutaneous penicilliosis lesions commonly appear on the face, ears, extremities, and occasionally the genitalia and are most commonly papules with central necrotic umbilication. We reported a 25-year-old male patient in Adam Malik General Hospital on April 26th2017 with of recurrent episodes of coughing and fever for 1 month. The patient had multiple papules in his skin which began to appear 3 months ago, which were soft, flocculating and tender, and yellow-whitish fluid oozed out when the papules became ulcerated. No specific allergic history or recent medication were reported. He had been diagnosed with HIV and Tuberculosis, and had received anti-retroviral and anti-tuberculosis therapy. Physical examination: multiple generalised subcutaneous nodules were seen on the face, ear, chest, abdomen and the extremities with purulent secretions. Laboratory examination: CD4+ T lymphocytes 64 cells/uL. Biopsy of the skin lesions confirmed penicilliosis, with the culture showing Penicillium marneffei. The patient completely recovered after being prescribed Itraconazole.