Association between CD8 T-cell subsets and CD4/CD8 ratio with HS-CRP level in HIV-infected patients on antiretroviral therapy

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Isabela, S.^1 ; Nugroho, A.^1 ; Harijanto, P.N.^1

Department of Tropical and Infectious Disease, Sam Ratulangi Faculty of Medicine, Prof Dr. R D Kandou General Hospital, North Sulawesi, Manado, Indonesia^1

关键词: Antiretrovirals;    Cross-sectional study;    General hospitals;    HIV patients;    Infected patients;    Negative correlation;    Positive correlations;    Spearman correlation;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012008/pdf
DOI  :  10.1088/1755-1315/125/1/012008

来源: IOP

【 摘 要 】

Due to improved access and adherence to antiretroviral therapy (ART), most HIV-infected persons worldwide are predicted to live longer. Nowadays the cause of death for most HIV-infected persons has changed to serious non-AIDS events (SNAEs) which is due to low-grade viremia. HIV patients with ART who had undergone CD4 cell count above 500/uL and there is an increase in hs-CRP despite an undetectable viral load. Some conditions CD8 cells count do not decrease with CD4 cells repairs. We researched in Prof Kandou General Hospital with a total sample of 35 HIV patients who had received ART with the level of CD4>350/uL. CD8 levels, CD4/CD8 ratio, and hs-CRP were assessed. This research is analytic descriptive with cross-sectional study design and analysis uses Spearman correlation. The mean CD8 during the study was 1291.8 (IQR 319-2610cells/uL), the mean ratio of CD4:CD8 was 0.57 (IQR 0.16-1.24) and median hs-CRP is 2.18 (IQR 0.3-6.6mg/dL). There was a significant positive correlation between CD8 and increased hs-CRP (r=0.369, p