Higher plasma CD4 lymphocyte count correlates with better cognitive function in human immunodeficiency virus-acquired immunodeficiency syndrome (HIV-AIDS) patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Fitri, F.I.^1 ; Rambe, A.S.^1 ; Fitri, A.^1

Department of Neurology, Faculty of Medicine Universitas Sumatera Utara, Jalan Bunga Lau No 17, Kemenangan Tani, Medan Tuntungan

20136, Indonesia^1

关键词: Acquired Immunodeficiency Syndrome;    Antiretrovirals;    Cognitive assessments;    Cognitive functions;    Cross-sectional study;    Human immunodeficiency virus;    Indonesians;    Mean ages;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012030/pdf
DOI  :  10.1088/1755-1315/125/1/012030

来源: IOP

【 摘 要 】

Neurocognitive disorders in HIV-AIDS are still prevalent despite the use of antiretroviral therapy and seem to be under-recognized. Plasma lymphocyte CD4 count is a marker for general immunology status, but its association with cognitive function remains unclear. The aim of this study was to determine the correlation between plasma CD4 lymphocyte and cognitive function in HIV-AIDS patients.This was a cross-sectional study involving 48 HIV-AIDS patients. All subjects underwent physical, neurologic examination and Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) to assess cognitive function and measurement of lymphocyte CD4 counts.This study included 48 subjects consisted of 29 males (60.4%) and 19 females (39.6%). The mean age was 39.17±11.21 years old. There was a significant correlation between CD4 lymphocyte counts and MoCA-INA score (r=0.347, p=0.016).Higher plasma CD4 lymphocyte count is correlated with better cognitive function in HIV-AIDS patients.